Committed to change the fate of neurodegenerative diseases
Committed to change the fate of neurodegenerative diseases
Mission
Our mission is the development of medicinal products to prevent, slow-down or even suppress the progression of neurodegenerative disease.
Vision
Our vision is contributing to a society where degenerative disease associated to aging will be controlled expanding the quality of life of elderly population and their relatives.
“When the steroid sulfatase gene is deleted in worms, the ability to remove sulfate from sulfated steroids is lost and the level of this molecule increases. This generates some surprising effects: nematodes with Alzheimer’s features reduce their symptoms and those without Alzheimer’s are long-lived”
Prof. Manuel Muñoz
Building on this observation, ONESTX developed LON-21, an oral first-in-class steroid sulfatase inhibitor demonstrated robust memory rescue and disease-modifying potential across amnesia, Alzheimer’s, and Huntington’s disease models. Our vision is to extend the therapeutic potential of this mechanism of action to other neurodegenerative diseases.
Partners
